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KMID : 1084220180250030203
Journal of Rheumatic Diseases
2018 Volume.25 No. 3 p.203 ~ p.206
Case of Raynaud Syndrome after the Use of Methimazole
Kim Yun-Kyung

Tag Hee-Sang
Kim Geun-Tae
Lee Seung-Geun
Park Eun-Kyung
Park Ji-Heh
Kweon Seong-Min
Yang Song-I
Kim Jeong-Hoon
Abstract
Raynaud syndrome is a medical condition that causes pain, numbness, and changes in skin color at the distal extremities. Raynaud syndrome can be subdivided into primary Raynaud's and secondary Raynaud's. The former is diagnosed when the cause is unknown and the latter is caused by an underlying condition, such as connective tissue diseases, injury, smoking, or certain medications. Both cancer chemotherapy and ¥â-blockers are relatively common causes of Raynaud syndrome but there are no reports of its association with methimazole administration. The authors encountered a 43-year old woman with hyperthyroidism who developed digital ulcers associated with Raynaud syndrome after a methimazole treatment. Her digital ulcers and Raynaud syndrome were improved after methimazole was replaced with propylthiouracil and conventional therapy. This paper reports this case along with a review of the relevant literature.
KEYWORD
Methimazole, Raynaud syndrome, Ulcer
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